Dextran

General Information (more on wikipedia)

Dextran is a complex, branched polysaccharide made of many glucose molecules joined into chains of varying lengths, used as an antithrombotic (anti-platelet), and to reduce blood viscosity.

The straight chain consists of α1->6 glycosidic linkages between glucose molecules, while branches begin from α1->3 linkages (and in some cases, α1->2 and α1->4 linkages as well). (For information on the numbering of carbon atoms in glucose, see the glucose article.) Dextran is synthesized from sucrose by certain lactic-acid bacteria, the best-known being Leuconostoc mesenteroides and Streptococcus mutans. Dental plaque is rich in dextrans.

Diffusion constant of Dextran 10 kDalton:

  • In water:
    • Alone:
  • In cytoplasm:
    • in D. melanogaster: $D = 29.1 \mu m^{2}/s$ [1]

Diffusion constant of Dextran 19 kDalton:

  • In water:
    • Alone:
    • FITC-Dextran: $D = 68.9 \mu m^{2}/s$ [2]
  • In cytoplasm:
    • Alone:

Diffusion constant of Dextran 40 kDalton:

  • In water:
    • Alone:
  • In cytoplasm:
    • in D. melanogaster: $D = 17.6 \mu m^{2}/s$ [1]

Diffusion constant of Dextran 70 kDalton:

  • In water:
    • Alone:
    • FITC-dextran: $D = 23 \mu m^{2}/s = 2.3 10^{-11} m^{2}/s$ [3]
  • In cytoplasm:
    • in D. melanogaster: $D = 15.3 \mu m^{2}/s$ [1]

Diffusion constant of Dextran 150 kDalton:

  • In water:
    • Alone:
    • FITC-Dextran: $D = 20.6 \mu m^{2}/s$ [2]
  • In cytoplasm:
    • in D. melanogaster: $D = 12.9 \mu m^{2}/s$ [1]
Bibliography
1. PNAS | December 20, 2005 | vol. 102 | no. 51 | 18403-18407
2. Volume 68 Issue 1 Page 95-102, September 1976
3. Biophys J. 1998 July; 75(1): 557–567
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